Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

Anne Brunet, Lora B. Sweeney, James Fitzhugh Sturgill et al. · Science · 2004 · 3.2K citations

Life Sciences, Biochemistry, Molecular Biology +15

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Joseph T. Rodgers, Carles Lerín, Wilhelm Haas et al. · Nature · 2005 · 3.1K citations

Life Sciences, Molecular Biology, Physiology +14

Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

Raúl Mostoslavsky, Katrin F. Chua, David B. Lombard et al. · Cell · 2006 · 1.6K citations · Full text

Medicine, Genetics, Molecular Biology +16

Normal growth and development in the absence of hepatic insulin-like growth factor I

Shoshana Yakar, Jun‐Li Liu, Bethel Stannard et al. · Proceedings of the National Academy of Sciences · 1999 · 1.4K citations

Life Sciences, Developmental Biology, Endocrinology +16

Mammalian SIRT1 Represses Forkhead Transcription Factors

Maria Carla Motta, Nullin Divecha, Madeleine E. Lemieux et al. · Cell · 2004 · 1.4K citations · Full text

Life Sciences, Genetics, Molecular Biology +9