Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

Rui-Hong Wang, Kundan Sengupta, Cuiling Li, +13

Cancer Cell

ChromatinGenome InstabilityDna DamageChromatin RemodelingGenetics +7

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

Rui-Hong Wang, Cuiling Li, Xiaoling Xu, +8

Cell Metabolism

Hepcidin ExpressionBiochemistryPositive RegulationIron MetabolismLiver Physiology +10

SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

Hyun‐Seok Kim, Athanassios Vassilopoulos, Rui-Hong Wang, +13

Cancer Cell

Suppresses TumorigenesisRegulating Apc/c ActivityCell RegulationMedicineTumor Suppressor +5

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

Hyun‐Seok Kim, Cuiying Xiao, Rui-Hong Wang, +9

Cell Metabolism

Metabolic SyndromeHepatologyBiochemistryHepatic-specific DisruptionMice Results +11

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis

Rui-Hong Wang, Zheng Yin, Hyun‐Seok Kim, +12

Molecular Cell

Tumor BiologyMedicineBrca1-associated TumorigenesisTumor SuppressorCancer Genetics +3

Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells

Su‐Mi Choi, Yonghak Kim, Joong Sup Shim, +7

Hepatology

SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice

Cuiying Xiao, Hyun‐Seok Kim, Tyler Lahusen, +6

Journal of Biological Chemistry

Sirt6 DeficiencyMetabolic DisorderApoptosisGlucose HomeostasisInsulin-stimulated Glucose Uptake +20

RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis

Vivek Shukla, Xavier Coumoul, Rui-Hong Wang, +2

Nature Genetics

SclerostinDevelopmental BiologySignaling PathwayBone Morphogenic ProteinRna Interference +6

Resveratrol Inhibits mTOR Signaling by Promoting the Interaction between mTOR and DEPTOR

Meilian Liu, Sarah Ann Wilk, Anping Wang, +6

Journal of Biological Chemistry

A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint

Rui-Hong Wang, Hongtao Yu, Chu‐Xia Deng

Proceedings of the National Academy of Sciences