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Synthesis and structure–activity relationships of new disubstituted phenyl-containing 3,4-diamino-3-cyclobutene-1,2-diones as CXCR2 receptor antagonists

Gaifa Lai, J. Robert Merritt, He Zhenmin, Daming Feng, Jianhua Chao, Michael Czarniecki, Laura L. Rokosz, Tara M. Stauffer, Diane Rindgen, Arthur G. Taveras

Bioorganic & Medicinal Chemistry Letters · 2008 · 10 citations · 18 references

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References

18

Structure and Functional Expression of a Human Interleukin-8 Receptor

William E. Holmes, James Lee, Wun-Jing Kuang et al. · Science · 1991 · 1.1K citations

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Cloning of Complementary DNA Encoding a Functional Human Interleukin-8 Receptor

Philip M. Murphy, H. Lee Tiffany · Science · 1991 · 885 citations · Full text

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Neutrophil and B Cell Expansion in Mice That Lack the Murine IL-8 Receptor Homolog

G Cacalano, James Lee, Kristine Kikly et al. · Science · 1994 · 662 citations

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A Potent and Selective Nonpeptide Antagonist of CXCR2 Inhibits Acute and Chronic Models of Arthritis in the Rabbit

Patricia L. Podolin, Brian Bolognese, James J. Foley et al. · The Journal of Immunology · 2002 · 162 citations

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Discovery of 2-Hydroxy-<i>N</i>,<i>N</i>-dimethyl-3-{2-[[(<i>R</i>)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123):  A Potent, Orally Bioavailable CXCR2/CXCR1 Receptor Antagonist

Michael P. Dwyer, Younong Yu, Jianping Chao et al. · Journal of Medicinal Chemistry · 2006 · 116 citations · Full text

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