Allosteric Control of Oligonucleotide Hybridization by Metal-Induced Cyclization

Mareike Göritz, Roland Krämer

Journal of the American Chemical Society · 2005 · 57 citations · 9 references

Concepts

Abstract

A bis(terpyridine) modified single-stranded DNA smoothly forms a stable cycle by Fe2+-assisted ring closure. A novel, complex type of allosteric behavior is observed with Zn2+, which reversibly off-regulates binding of a complementary oligonucleotide only in a narrow concentration range.

References

9