Concepedia

Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation

Yiming Jiang, Xiaomei Fan, Ying Wang, Huasen Tan, Pan Chen, Hang Zeng, Min Huang, Huichang Bi

Chemico-Biological Interactions · 2015 · 117 citations · 24 references

DOI

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References

24

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

Mitchell R. McGill, Matthew R. Sharpe, C. David Williams et al. · Journal of Clinical Investigation · 2012 · 763 citations · Full text

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Protection against Acetaminophen Toxicity in CYP1A2 and CYP2E1 Double-Null Mice

Hani Zaher, Jeroen Buters, Jerrold M. Ward et al. · Toxicology and Applied Pharmacology · 1998 · 322 citations

, , +9

Traditional Chinese Medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) Activate Pregnane X Receptor and Increase Warfarin Clearance in Rats

Ying Mu, Jinnan Zhang, Shimin Zhang et al. · Journal of Pharmacology and Experimental Therapeutics · 2006 · 165 citations

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IDENTIFICATION AND CHARACTERIZATION OF POTENT CYP3A4 INHIBITORS IN SCHISANDRA FRUIT EXTRACT

Hiroshi Iwata, Yasuhiro Tezuka, Shigetoshi Kadota et al. · Drug Metabolism and Disposition · 2004 · 154 citations

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Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure

Suraj J. Patel, Jack M. Milwid, Kevin R. King et al. · Nature Biotechnology · 2012 · 122 citations

, , +14