Matthew R. Sharpe

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

Mitchell R. McGill, Matthew R. Sharpe, C. David Williams et al. · Journal of Clinical Investigation · 2012 · 732 citations · Full text

Mitochondrial Dysfunction, Cell Death, Pathology +19

RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

Daniel J. Antoine, Rosalind E. Jenkins, James W. Dear et al. · Journal of Hepatology · 2012 · 306 citations · Full text

Hepatology, Mechanistic Biomarkers, Medicine +8

Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans

C. David Williams, Mary Lynn Bajt, Matthew R. Sharpe et al. · Toxicology and Applied Pharmacology · 2014 · 168 citations

Inflammation, Neutrophil Activation, Anti-inflammatory +15

Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome

Mitchell R. McGill, Vincent S. Staggs, Matthew R. Sharpe et al. · Hepatology · 2014 · 161 citations · Full text

Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans

Mitchell R. McGill, Feng Li, Matthew R. Sharpe et al. · Archives of Toxicology · 2013 · 141 citations · Full text

Mitochondrial Function, Mitochondrial Dysfunction, Physiology +10