Concepedia

At Tachment of Cholesterol to Amino-LNA: Synthesis and Hybridization Properties

Torsten Bryld, Christian Lomholt

Nucleosides Nucleotides & Nucleic Acids · 2007 · 12 citations · 4 references

DOI

Concepts

Abstract

Here, we present our synthesis of amino-LNA with a C6-linker and hybridization studies of these. A cholesterol moiety was attached at the end of the C6-linker. This resulted in drastic drops against DNA of the modified oligonucleotide.

References

4

Silencing of microRNAs in vivo with ‘antagomirs’

Jan Krützfeldt, Nikolaus Rajewsky, Ravi Braich et al. · Nature · 2005 · 4K citations

, , +11

LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

Alexei A. Koshkin, Sanjay K. Singh, Poul Nielsen et al. · Tetrahedron · 1998 · 1K citations

, , +16

Functionalized LNA (locked nucleic acid): high-affinity hybridization of oligonucleotides containing N-acylated and N-alkylated 2′-amino-LNA monomers

Mads D. Sørensen, Michael Petersen, Jesper Wengel · Chemical Communications · 2003 · 89 citations

, , +17

Synthesis of bridged dinucleosides

D. C. AGATHOCLEOUS, Philip C. Bulman Page, Richard Cosstick et al. · Tetrahedron · 1990 · 12 citations

, , +7