Concepedia

Lna Synthesis

LNA Synthesis is a chemical methodology in nucleic acid chemistry that involves the stereoselective preparation of locked nucleic acid monomers and their incorporation into oligonucleotide sequences to enhance binding affinity and nuclease resistance through conformational restriction of the sugar moiety.

92

Publications

5.9K

Citations

250

Authors

82

Institutions

Publications per year

2017–2026

11

Parents

Publications

92

LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

Alexei A. Koshkin, Sanjay K. Singh, Poul Nielsen et al. · Tetrahedron · 1998 · 1K citations

, , +16

LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

Sanjay K. Singh, Alexei A. Koshkin, Jesper Wengel et al. · Chemical Communications · 1998 · 770 citations

, , +16

LNA (Locked Nucleic Acid):  An RNA Mimic Forming Exceedingly Stable LNA:LNA Duplexes

Alexei A. Koshkin, Poul Nielsen, Michael Meldgaard et al. · Journal of the American Chemical Society · 1998 · 339 citations

, , +12

Synthesis of 3‘-<i>C</i>- and 4‘-<i>C</i>-Branched Oligodeoxynucleotides and the Development of Locked Nucleic Acid (LNA)

Jesper Wengel · Accounts of Chemical Research · 1998 · 334 citations

, , +12

The first analogues of LNA (Locked Nucleic Acids): Phosphorothioate-LNA and 2′-thio-LNA

Ravindra Kumar, Sanjay K. Singh, Alexei A. Koshkin et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 218 citations

, , +13

1–5 of 92

Authors

250

  1. JW
    Jesper Wengel

    University of Southern Denmark, Denmark

    36 publications · 4K citations

    23

    h-index

  2. AA
    Alexei A. Koshkin

    University of Copenhagen, Denmark

    8 publications · 2.7K citations

    8

    h-index

  3. PJ
    Patrick J. Hrdlicka

    University of Idaho, United States

    8 publications · 205 citations

    8

    h-index

  4. VK
    Vivek K. Rajwanshi

    University of Copenhagen, Denmark

    8 publications · 1.9K citations

    8

    h-index

  5. PN
    Poul Nielsen

    University of Southern Denmark, Denmark

    7 publications · 2.2K citations

    7

    h-index

1–5 of 250

Institutions

82

  1. University of Southern Denmark

    Odense, Denmark

    18 h-index

    74 publications

    4.3K citations

  2. University of Copenhagen

    Copenhagen, Denmark

    17 h-index

    64 publications

    14.3K citations

  3. University of Idaho

    Moscow, United States

    7 h-index

    24 publications

    580 citations

  4. The University of Osaka

    Osaka, Japan

    6 h-index

    31 publications

    2.1K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    17 publications

    323 citations

  6. Uppsala University

    Uppsala, Sweden

    4 h-index

    16 publications

    796 citations

  7. Ionis Pharmaceuticals (United States)

    Carlsbad, United States

    3 h-index

    17 publications

    974 citations

  8. Roche (Switzerland)

    Basel, Switzerland

    3 h-index

    13 publications

    378 citations

1–8 of 82

Venues

  1. The Journal of Organic Chemistry

    JOC · 14 publications · 571 citations

    13

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    8 publications · 339 citations

    8

    h-index

  3. Chemical Communications

    ChemComm · 8 publications · 1K citations

    8

    h-index

  4. Organic & Biomolecular Chemistry

    7 publications · 180 citations

    7

    h-index

  5. Journal of the American Chemical Society

    JACS · 6 publications · 869 citations

    6

    h-index

1–5