Discovery of imidazolidine-2,4-dione-linked HIV protease inhibitors with activity against lopinavir-resistant mutant HIV

Antiretroviral drug resistance testing in adult HIV-1 infection: recommendations of an International AIDS Society-USA Panel.

PubMed · 2000 · 783 citations

Life Sciences, Infectious Diseases, Microbiology +15

ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease

Hing L. Sham, Dale J. Kempf, Akhteruzammen Molla et al. · Antimicrobial Agents and Chemotherapy · 1998 · 470 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +16

Novel <i>bis</i> -Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human Immunodeficiency Virus In Vitro

Yasuhiro Koh, Hirotomo Nakata, Kenji Maeda et al. · Antimicrobial Agents and Chemotherapy · 2003 · 366 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Identification of Genotypic Changes in Human Immunodeficiency Virus Protease That Correlate with Reduced Susceptibility to the Protease Inhibitor Lopinavir among Viral Isolates from Protease Inhibitor-Experienced Patients

Dale J. Kempf, Jeffrey D. Isaacson, Martin King et al. · Journal of Virology · 2001 · 233 citations

Life Sciences, Genetics, Infectious Diseases +17

Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy

Dale J. Kempf, Hing L. Sham, Kennan C. Marsh et al. · Journal of Medicinal Chemistry · 1998 · 207 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17