Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase

Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.

R K Jain, Laurence T. Baxter · PubMed · 1988 · 715 citations

Medicine, Cancer Biology, Oncology +17

Antibody directed enzymes revive anti-cancer prodrugs concept

K D Bagshawe · British Journal of Cancer · 1987 · 278 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +12

A cytotoxic agent can be generated selectively at cancer sites

K D Bagshawe, Springer Cj, F Searle et al. · British Journal of Cancer · 1988 · 265 citations · Full text

Medicine, Cancer Biology, Oncology +11

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)—I

Gillian M. Anlezark, Roger G. Melton, Roger F. Sherwood et al. · Biochemical Pharmacology · 1992 · 215 citations

Life Sciences, Biochemistry, Medicinal Chemistry +3

Defective DNA cross-link removal in Chinese hamster cell mutants hypersensitive to bifunctional alkylating agents.

C. A. Hoy, Larry H. Thompson, Carolyn L. Mooney et al. · PubMed · 1985 · 208 citations

Life Sciences, Genetics, Dna Repair +16