Roger G. Melton

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)—I

Gillian M. Anlezark, Roger G. Melton, Roger F. Sherwood et al. · Biochemical Pharmacology · 1992 · 215 citations

Life Sciences, Biochemistry, Medicinal Chemistry +3

Purification and properties of carboxypeptidase G2 from Pseudomonas sp. strain RS-16. Use of a novel triazine dye affinity method

Roger F. Sherwood, Roger G. Melton, Shakir M. Alwan et al. · European Journal of Biochemistry · 1985 · 210 citations · Full text

Life Sciences, Biochemistry, Biotechnology +16

Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy

Siân Rowsell, Richard A. Pauptit, Alec D. Tucker et al. · Structure · 1997 · 191 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +8

Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy.

Richard J. Knox, Terence C. Jenkins, Stephen M. Hobbs et al. · PubMed · 2000 · 117 citations

Medicine, Oncology, Pharmacology +16

Ablation of human choriocarcinoma xenografts in nude mice by antibody-directed enzyme prodrug therapy (ADEPT) with three novel compounds

Caroline J. Springer, Kenneth D. Bagshawe, Surinder K. Sharma et al. · European Journal of Cancer and Clinical Oncology · 1991 · 116 citations

Pharmacy, Oncology, Pharmacology +15