Richard J. Knox

Mechanism of cytotoxicity of anticancer platinum drugs: evidence that cis-diamminedichloroplatinum(II) and cis-diammine-(1,1-cyclobutanedicarboxylato)platinum(II) differ only in the kinetics of their interaction with DNA.

Richard J. Knox, Frank Friedlos, David Lydall et al. · PubMed · 1986 · 499 citations

Medicine, Oncology, Pharmacology +15

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)—I

Gillian M. Anlezark, Roger G. Melton, Roger F. Sherwood et al. · Biochemical Pharmacology · 1992 · 215 citations

Life Sciences, Biochemistry, Medicinal Chemistry +3

A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in walker carcinoma cells

Richard J. Knox, Frank Friedlos, Michael Jarman et al. · Biochemical Pharmacology · 1988 · 166 citations

Medicine, Cancer Biology, Oncology +9

The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)

Richard J. Knox, Marion P. Boland, Frank Friedlos et al. · Biochemical Pharmacology · 1988 · 150 citations

Life Sciences, Biochemistry, Molecular Biology +9

Catalytic Properties of NAD(P)H:Quinone Oxidoreductase-2 (NQO2), a Dihydronicotinamide Riboside Dependent Oxidoreductase

Kebin Wu, Richard J. Knox, Xiu Zhu Sun et al. · Archives of Biochemistry and Biophysics · 1997 · 142 citations

Life Sciences, Biochemistry, Molecular Biology +12