Concepedia

The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells

Masazumi Nagai, Nha Huu Vo, Luisa Shin Ogawa, Dinesh Chimmanamada, Takayo Inoue, John Man Tak Chu, Britte Beaudette-Zlatanova, Rongzhen Lu, Ronald K. Blackman, James Barsoum,

Free Radical Biology and Medicine · 2012 · 354 citations · 13 references

DOI

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13

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

Lakshmi Raj, Takao Ide, Aditi U. Gurkar et al. · Nature · 2011 · 1K citations

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The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria

Judy Hirst · Proceedings of the National Academy of Sciences · 2006 · 712 citations · Full text

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Elesclomol induces cancer cell apoptosis through oxidative stress

Jessica R. Kirshner, Suqin He, Vishwasenani Balasubramanyam et al. · Molecular Cancer Therapeutics · 2008 · 352 citations · Full text

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Structure-Function Relationships in Lactate Dehydrogenase

Margaret Adams, Manfred Buehner, K. Chandrasekhar et al. · Proceedings of the National Academy of Sciences · 1973 · 259 citations · Full text

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Phase II, Randomized, Controlled, Double-Blinded Trial of Weekly Elesclomol Plus Paclitaxel Versus Paclitaxel Alone for Stage IV Metastatic Melanoma

Steven O’Day, René González, David H. Lawson et al. · Journal of Clinical Oncology · 2009 · 210 citations · Full text

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