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Intramolecular base-accelerated radical-scavenging reaction of a planar catechin derivative bearing a lysine moiety

Kiyoshi Fukuhara, Ikuo Nakanishi, Kei Ohkubo, Yoshinori Obara, Ayako Tada, Kohei Imai, Akiko Ohno, Asao Nakamura, Toshihiko Ozawa, Shiro Urano,

Chemical Communications · 2009 · 15 citations · 10 references

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Abstract

A planar catechin derivative incorporating a lysine moiety was synthesized and showed approximately 400-fold increased radical-scavenging activity relative to naturally-occurring (+)-catechin.

References

10

Flavonoid B-Ring Chemistry and Antioxidant Activity: Fast Reaction Kinetics

Ananth Sekher Pannala, Tom S. Chan, Peter J. O’Brien et al. · Biochemical and Biophysical Research Communications · 2001 · 459 citations

, , +7

Antioxidant Activity and Radioprotective Effects against Chromosomal Damage Induced in Vivo by X-rays of Flavan-3-ols (Procyanidins) from Grape Seeds (<i>Vitis vinifera</i>):  Comparative Study versus Other Phenolic and Organic Compounds

J. Castillo, O. Benavente-García, J. Lorente et al. · Journal of Agricultural and Food Chemistry · 2000 · 170 citations

, , +13

Electron-transfer mechanism in radical-scavenging reactions by a vitamin E model in a protic medium

Ikuo Nakanishi, Tomonori Kawashima, Kei Ohkubo et al. · Organic & Biomolecular Chemistry · 2005 · 127 citations · Full text

, , +14

Enhanced Radical-Scavenging Activity of a Planar Catechin Analogue

Kiyoshi Fukuhara, Ikuo Nakanishi, Hisao Kansui et al. · Journal of the American Chemical Society · 2002 · 92 citations · Full text

, , +9

Planar Catechin Analogues with Alkyl Side Chains:  A Potent Antioxidant and an α-Glucosidase Inhibitor

Wataru Hakamata, Ikuo Nakanishi, Yu Masuda et al. · Journal of the American Chemical Society · 2006 · 75 citations

, , +16