Enhanced Radical-Scavenging Activity of a Planar Catechin Analogue

Kiyoshi Fukuhara, Ikuo Nakanishi, Hisao Kansui, Etsuko Sugiyama, Mitsuhiro Kimura, Tomokazu Shimada, Shiro Urano, Kentaro Yamaguchi, Naoki Miyata

Journal of the American Chemical Society · 2002 · 92 citations · 20 references

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Abstract

A catechin analogue in which the geometry was constrained to be planar was synthesized. The planar catechin showed excellent radical-scavenging ability, comparable to that of quercetin, and efficient protection against DNA strand breakage induced by the Fenton reaction.

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