Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: Design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

Rudi Pauwels, Jan Balzarini, Masanori Baba et al. · Journal of Virological Methods · 1988 · 1.6K citations

Life Sciences, Infectious Diseases, Analytical Chemistry +12

The maximal affinity of ligands

Irwin D. Kuntz, K. Chen, Kim A. Sharp et al. · Proceedings of the National Academy of Sciences · 1999 · 845 citations

Natural Sciences, Chemistry, Biophysical Chemistry +16

Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later

Christophe Pannecouque, Dirk Daelemans, Erik De Clercq · Nature Protocols · 2008 · 349 citations

Life Sciences, Infectious Diseases, Molecular Biology +14

Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design

E.B. Lansdon, Katherine M. Brendza, Magdeleine Hung et al. · Journal of Medicinal Chemistry · 2010 · 226 citations

Life Sciences, Medicinal Chemistry, Molecular Biology +17

Strategies for the Design of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Lessons from the Development of Seven Representative Paradigms

Dongyue Li, Peng Zhan, Erik De Clercq et al. · Journal of Medicinal Chemistry · 2012 · 121 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17