Clinical targeting of HIV capsid protein with a long-acting small molecule

John O. Link, Martin S. Rhee, Winston C. Tse, +70

Nature

Natural SciencesHuman RetrovirusImmunologyAntiviral TherapyMolecular Biology +8

PD-1 blockade partially recovers dysfunctional virus–specific B cells in chronic hepatitis B infection

Loghman Salimzadeh, Nina Le Bert, Charles‐Antoine Dutertre, +8

Journal of Clinical Investigation

Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design

E.B. Lansdon, Katherine M. Brendza, Magdeleine Hung, +6

Journal of Medicinal Chemistry

Biomolecular Structure PredictionMolecular BiologyAntiviral DrugResistance MutationsDrug Resistance +14

New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

Manuel Tsiang, G.S. Jones, Anita Niedziela‐Majka, +13

Journal of Biological Chemistry

Hiv-1 IntegraseMedicineHuman RetrovirusImmunologyAntiviral Drug Development +8

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

Stephen R. Yant, Andrew Mulato, Derek Hansen, +27

Nature Medicine

MedicineHuman RetrovirusImmunologyAntiviral ResponseAntiviral Drug Development +6

Importance of Ribosomal Frameshifting for Human Immunodeficiency Virus Type 1 Particle Assembly and Replication

Magdeleine Hung, Pratiksha Patel, Susan L. Davis, +1

Journal of Virology

Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9

T.C. Appleby, Andrew E. Greenstein, Magdeleine Hung, +11

Journal of Biological Chemistry

Matrix Metalloproteinase 9ImmunologyPathologyImmunotherapyCancer Biology +22

Comparative characterization of B cells specific for HBV nucleocapsid and envelope proteins in patients with chronic hepatitis B

Nina Le Bert, Loghman Salimzadeh, Upkar S. Gill, +9

Journal of Hepatology

Viral PersistenceHepatologyViral HepatitisImmunologyHepatitis B +9

Toll‐Like Receptor 8 Agonist GS‐9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B

Stéphane Daffis, Scott Balsitis, Jason Chamberlain, +22

Hepatology

Hepatitis B core-specific memory B cell responses associate with clinical parameters in patients with chronic HBV

Thomas Vanwolleghem, Zwier M. A. Groothuismink, Kim Kreefft, +3

Journal of Hepatology

HepatologyViral HepatitisMedicineImmunologyHepatitis B +8