Publication | Closed Access
Bioaffinity NMR Spectroscopy: Identification of an E-Selectin Antagonist in a Substance Mixture by Transfer NOE
78
Citations
0
References
1999
Year
Transfer NoeE-selectin Antagonist 1Medicinal ChemistryBioanalysisElectron Paramagnetic ResonancePotential E-selectin LigandsBioaffinity Nmr SpectroscopyBiochemistryMechanism Of ActionNeuropharmacologyPharmacologyE-selectin AntagonistFunctional SelectivityNatural SciencesMagnetic Resonance SpectroscopyProtein NmrChemical ProbeMedicineDrug Discovery
Unambiguous identification of the E-selectin antagonist 1 in a mixture of potential E-selectin ligands is possible with a bioactivity assay that is based on transfer NOE. This is remarkable, since the compounds present in the mixture have similar structures and their 1H NMR signals overlap extensively.