Concepedia

Target-ligand Selectivity

Target-Ligand Selectivity is a biochemical property denoting the specificity with which a ligand binds to a particular molecular target over other potential off-target biomolecules, distinguished by its capacity to discriminate functional interactions from non-specific binding events in the context of target deconvolution.

117

Publications

5.6K

Citations

744

Authors

263

Institutions

Publications per year

2017–2026

40

Parents

Publications

117

Structure-activity profile of calcitonin gene-related peptide in peripheral and brain tissues. Evidence for receptor multiplicity.

T Dennis, Alain Fournier, S. St. Pierre et al. · Journal of Pharmacology and Experimental Therapeutics · 1989 · 228 citations

, , +17

Target Selectivity of Vertebrate Notch Proteins

Chin‐Tong Ong, Hui‐Teng Cheng, Li‐Wei Chang et al. · Journal of Biological Chemistry · 2005 · 218 citations · Full text

, , +12

Combinatorial target-guided ligand assembly: Identification of potent subtype-selective c-Src inhibitors

Dustin J. Maly, Ingrid Choong, Jonathan A. Ellman · Proceedings of the National Academy of Sciences · 2000 · 188 citations · Full text

, , +17

Discovery of a Potential Allosteric Ligand Binding Site in CDK2

S. Betzi, Riazul Alam, Mathew P. Martin et al. · ACS Chemical Biology · 2011 · 185 citations

, , +16

Interleukin 1β-converting Enzyme Related Proteases/Caspases Are Involved in TRAIL-induced Apoptosis of Myeloma and Leukemia Cells

Sara M Mariani, Bernd Matiba, Elena Armandola et al. · The Journal of Cell Biology · 1997 · 143 citations · Full text

, , +17

1–5 of 117

Authors

744

  1. DH
    David Hecht

    Southwestern College - California, United States

    3 publications · 124 citations

    3

    h-index

  2. JL
    Jeffrey L. Gustafson

    San Diego State University, United States

    3 publications · 124 citations

    3

    h-index

  3. BE
    Beat Ernst

    University of Basel, Switzerland

    2 publications · 132 citations

    2

    h-index

  4. TI
    Taisen Iguchi

    National Institute for Basic Biology, Japan

    2 publications · 61 citations

    2

    h-index

  5. AH
    Akira Hasegawa

    Gifu University, Japan

    2 publications · 100 citations

    2

    h-index

1–5 of 744

Institutions

263

  1. The Ohio State University

    Columbus, United States

    4 h-index

    8 publications

    372 citations

  2. University of California San Diego

    San Diego, United States

    4 h-index

    4 publications

    182 citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    11 publications

    386 citations

  4. University of Oxford

    Oxford, United Kingdom

    3 h-index

    9 publications

    170 citations

  5. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    22 publications

    1.1K citations

  6. Kyoto University

    Kyoto, Japan

    3 h-index

    17 publications

    1.5K citations

  7. University of Toronto

    Toronto, Canada

    3 h-index

    9 publications

    220 citations

  8. University of California, Berkeley

    Berkeley, United States

    3 h-index

    16 publications

    1.2K citations

1–8 of 263

Venues

  1. Journal of Medicinal Chemistry

    16 publications · 692 citations

    15

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 7 publications · 521 citations

    7

    h-index

  3. Journal of Biological Chemistry

    JBC · 6 publications · 597 citations

    6

    h-index

  4. Angewandte Chemie International Edition

    5 publications · 363 citations

    5

    h-index

  5. FEBS Letters

    4 publications · 218 citations

    4

    h-index

1–5