Concepedia

Bioactivity Assay Development

Bioactivity Assay Development is the systematic design and optimization of analytical methods used to measure the biological activity of chemical compounds during hit-to-lead progression, distinguished by its focus on establishing robust, reproducible, and biologically relevant quantitative readouts that enable structure-activity relationship evaluation and compound prioritization.

145

Publications

9K

Citations

795

Authors

291

Institutions

Publications per year

2017–2026

34

Parents

Publications

145

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

Jonathan B. Baell, Georgina A. Holloway · Journal of Medicinal Chemistry · 2010 · 3.9K citations

, , +14

The sulphorhodamine (SRB) assay and other approaches to testing plant extracts and derived compounds for activities related to reputed anticancer activity

Peter J. Houghton, Rui Fang, Isariya Techatanawat et al. · Methods · 2007 · 333 citations

, , +11

Evaluation of major constraints to revegetation of lead/zinc mine tailings using bioassay techniques

Z.H. Ye, W.S. Shu, Z.Q. Zhang et al. · Chemosphere · 2002 · 211 citations

, , +16

Use of Reference Compounds in Antioxidant Activity Assessment

Nikolaos Nenadis, Olga Lazaridou, María Z. Tsimidou · Journal of Agricultural and Food Chemistry · 2007 · 155 citations

, , +12

Coupling HPLC to on-line, post-column (bio)chemical assays for high-resolution screening of bioactive compounds from complex mixtures

Yuping Zhang, Xinyu Jiang, Hong‐Hao Zhou et al. · TrAC Trends in Analytical Chemistry · 2009 · 130 citations

, , +17

1–5 of 145

Authors

795

  1. JP
    John P. Giesy

    University of Saskatchewan, Canada

    2 publications · 71 citations

    2

    h-index

  2. LM
    Lijuan Mei

    Chinese Academy of Sciences, China

    2 publications · 63 citations

    2

    h-index

  3. JK
    Justin Klekota

    Harvard University, United States

    2 publications · 41 citations

    2

    h-index

  4. TL
    Tzong‐Huei Lee

    National Taiwan University, Taiwan

    2 publications · 35 citations

    2

    h-index

  5. JS
    Jong Seong Khim

    Seoul National University, South Korea

    2 publications · 71 citations

    2

    h-index

1–5 of 795

Institutions

291

  1. Chinese Academy of Sciences

    Beijing, China

    5 h-index

    30 publications

    818 citations

  2. Nanjing University

    Nanjing, China

    3 h-index

    11 publications

    388 citations

  3. National Taiwan University

    Taipei, Taiwan

    3 h-index

    3 publications

    53 citations

  4. AbbVie (United States)

    North Chicago, United States

    2 h-index

    3 publications

    87 citations

  5. Vertex Pharmaceuticals (United States)

    Boston, United States

    2 h-index

    11 publications

    556 citations

  6. Gdańsk Medical University

    Gdansk, Poland

    2 h-index

    5 publications

    116 citations

  7. Al-Azhar University

    Cairo, Egypt

    2 h-index

    3 publications

    66 citations

  8. Meikai University

    Saitama, Japan

    2 h-index

    3 publications

    41 citations

1–8 of 291

Venues

  1. Journal of Agricultural and Food Chemistry

    8 publications · 433 citations

    8

    h-index

  2. SLAS DISCOVERY

    6 publications · 151 citations

    5

    h-index

  3. Journal of Medicinal Chemistry

    4 publications · 4.1K citations

    4

    h-index

  4. Journal of Chemical Information and Modeling

    JCIM · 3 publications · 61 citations

    3

    h-index

  5. TrAC Trends in Analytical Chemistry

    3 publications · 176 citations

    3

    h-index

1–5