Concepedia

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

Sarah Doyle, Matthew Campbell, Ema Ozaki, Robert G. Salomon, Andrés Mori, Paul F. Kenna, G. Jane Farrar, Anna‐Sophia Kiang, Marian M. Humphries, Ed C. Lavelle,

Nature Medicine · 2012 · 420 citations · 51 references

DOI

Concepts

References

51

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

Alexander Poltorak, Xiaolong He, Irina Smirnova et al. · Science · 1998 · 7.6K citations

, , +17

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou, Amir S. Yazdi, Philippe Menu et al. · Nature · 2010 · 5.4K citations

, , +12

Gout-associated uric acid crystals activate the NALP3 inflammasome

Fabio Martinon, Virginie Pétrilli, Annick Mayor et al. · Nature · 2006 · 5.2K citations

, , +11

Global data on visual impairment in the year 2002.

Serge Resnikoff, Donatella Pascolini, Daniel Etya’ale et al. · PubMed · 2004 · 4.2K citations

, , +16

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Peter Duewell, Hajime Kono, Katey J. Rayner et al. · Nature · 2010 · 3.9K citations · Full text

, , +12