NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

Sarah Doyle, Matthew Campbell, Ema Ozaki, +10

Nature Medicine

InflammationOcular DiseaseAutoimmune DiseaseOphthalmologyAge-related Diseases +9

RNA Interference–Mediated Suppression and Replacement of Human Rhodopsin In Vivo

Mary O’Reilly, Arpad Palfi, Naomi Chadderton, +13

The American Journal of Human Genetics

Systems BiologyMolecular PhysiologyEngineeringRna Binding ProteinsHuman Rhodopsin +5

RNAi‐mediated reversible opening of the blood‐brain barrier

Matthew Campbell, Anna‐Sophia Kiang, Paul F. Kenna, +8

The Journal of Gene Medicine

NanotherapeuticsTransient Barrier OpeningEngineeringMolecular BiologyBiomedical Engineering +19

IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration

Sarah Doyle, Ema Ozaki, Kiva Brennan, +14

Science Translational Medicine

Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury

Matthew Campbell, Finnian Hanrahan, Oliviero L. Gobbo, +14

Nature Communications

Retinitis Pigmentosa and Progressive Sensorineural Hearing Loss Caused by a C12258A Mutation in the Mitochondrial MTTS2 Gene

Fiona C. Mansergh, Sophia Millington‐Ward, Avril Kennan, +5

The American Journal of Human Genetics

C12258a MutationMendelian DisorderMitochondrial FunctionGenetic DisorderRetinitis Pigmentosa +9

A novel mutation within the rhodopsin gene (Thr-94-Ile) causing autosomal dominant congenital stationary night blindness

Najma al-Jandal, G. Jane Farrar, Anna‐Sophia Kiang, +5

Human Mutation

Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma

Jeffrey O’Callaghan, Darragh E. Crosbie, Paul Cassidy, +13

Human Molecular Genetics

Therapeutic PotentialGlaucomatous AhOcular DiseaseCellular PhysiologyInflammation +14

Toward a Gene Therapy for Dominant Disease: Validation of an RNA Interference-Based Mutation-Independent Approach

Anna‐Sophia Kiang, Arpad Palfi, Marius Ader, +10

Molecular Therapy

EngineeringDominant DiseaseGeneticsGenomic MechanismReplacement Genes +16

An experimental platform for systemic drug delivery to the retina

Matthew Campbell, Anh T. H. Nguyen, Anna‐Sophia Kiang, +8

Proceedings of the National Academy of Sciences

Systemic Drug DeliveryOcular DiseaseImmunologyOptogeneticsNanomedicine +15