Concepedia

The Dileucine-Based Sorting Motif in HIV-1 Nef Is Not Required for Down-Regulation of Class I MHC

Nanette L. Riggs, Heather M. Craig, Mark Pandori, John Guatelli

Virology · 1999 · 74 citations · 20 references

DOI

Concepts

References

20

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

Olivier Schwartz, Valerie Maréchal, Sylvie Le Gall et al. · Nature Medicine · 1996 · 1.1K citations

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Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

J. Victor Garcia, A. Dusty Miller · Nature · 1991 · 760 citations

, , +9

Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

Christopher Aiken, Jason Konner, Nathaniel R. Landau et al. · Cell · 1994 · 697 citations

, , +14

Proline‐rich (PxxP) motifs in HIV‐1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down‐regulation of CD4.

Kalle Saksela, Genhong Cheng, David Baltimore · The EMBO Journal · 1995 · 555 citations · Full text

, , +15

Nef Interacts with the μ Subunit of Clathrin Adaptor Complexes and Reveals a Cryptic Sorting Signal in MHC I Molecules

Sylvie Le Gall, Lars Erdtmann, Serge Bénichou et al. · Immunity · 1998 · 383 citations · Full text

, , +16