Decay characteristics of HIV-1-infected compartments during combination therapy

Alan S. Perelson, Paulina Essunger, Yunzhen Cao, +5

Nature

Decay CharacteristicsHuman RetrovirusImmunologyAntiviral TherapyAntiviral Response +5

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.

Kalle Saksela, Genhong Cheng, David Baltimore

The EMBO Journal

Viral ReplicationSignal TransductionHuman RetrovirusHiv-1 Nef BindAntiviral Response +8

Crystal Structure of the Conserved Core of HIV-1 Nef Complexed with a Src Family SH3 Domain

Chi‐Hon Lee, Kalle Saksela, Urooj A. Mirza, +2

Cell

Conserved CoreVirus StructureCrystal StructureBiochemistryMedicine +8

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein.

Chi‐Hon Lee, Bonnie W. Leung, Mark A. Lemmon, +4

The EMBO Journal

Virus StructureViral ReplicationBiochemistryNatural SciencesHuman Retrovirus +10

Distinct modes of human immunodeficiency virus type 1 proviral latency revealed by superinfection of nonproductively infected cell lines with recombinant luciferase-encoding viruses

Benjamin K. Chen, Kalle Saksela, Raul Andino, +1

Journal of Virology

Viral ReplicationDistinct ModesImmunologyImmunotherapyViral Persistence +14

High-Throughput Phosphotyrosine Profiling Using SH2 Domains

Kazuya Machida, Christopher M. Thompson, Kevin Dierck, +13

Molecular Cell

BiochemistryNatural SciencesBioanalysisComputational BiologyMolecular Biology +2

T cell circuits that sense antigen density with an ultrasensitive threshold

Rogelio A. Hernández‐López, Wei Yu, Katelyn A. Cabral, +8

Science

The Hepatitis C Virus Non-structural NS5A Protein Inhibits Activating Protein–1 Function by Perturbing Ras-ERK Pathway Signaling

Andrew Macdonald, Katherine Crowder, Andrew Street, +3

Journal of Biological Chemistry

Viral ReplicationImmunologyViral Structural ProteinSignaling PathwayCell Regulation +16

Harnessing Endogenous miRNAs to Control Virus Tissue Tropism as a Strategy for Developing Attenuated Virus Vaccines

Dwight Barnes, Mark Kunitomi, Marco Vignuzzi, +2

Cell Host & Microbe

VaccinationViral ReplicationViral PathogenesisImmunologyVirology +6

SH3 Domain-Mediated Recruitment of Host Cell Amphiphysins by Alphavirus nsP3 Promotes Viral RNA Replication

Maarit Neuvonen, Arūnas Kazlauskas, Miika Martikainen, +3

PLoS Pathogens

Viral ReplicationMolecular BiologyAlphavirus InfectionVirus StructureHost Cell Amphiphysins +14