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Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: Indoloquinones and diaziridinyl benzoquinones

Samantha Bailey, N. Suggett, Michael I. Walton, Paul Workman

International Journal of Radiation Oncology*Biology*Physics · 1992 · 42 citations · 11 references

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11

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Tim R. Mosmann · Journal of Immunological Methods · 1983 · 55.6K citations

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Dt diaphorase I. Purification from the soluble fraction of rat-liver cytoplasm, and properties

Lars Ernster, L. L. Danielson, M. Ljunggren · Biochimica et Biophysica Acta · 1962 · 483 citations

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The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)

Richard J. Knox, Marion P. Boland, Frank Friedlos et al. · Biochemical Pharmacology · 1988 · 150 citations

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Metabolism of diaziquone by NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells.

David Siegel, Neil W. Gibson, Peter C. Preusch et al. · PubMed · 1990 · 128 citations

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Mitomycin analogs I. Indoloquinones as (potential) bisalkylating agents

E. A. OOSTVEEN, W. N. SPECKAMP · Tetrahedron · 1987 · 81 citations

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