Antioxidative Phenolic Compounds from Sage (<i>Salvia officinalis</i>)

TLDR

Ten phenolic compounds were isolated from a butanol fraction of sage extracts, their structures determined by NMR, MS, and IR, and their antioxidant activity was evaluated using DPPH and ABTS•+ assays. A novel compound, 4‑hydroxyacetophenone‑4‑O‑β‑d‑apiofuranosyl-(1→6)-O‑β‑d‑glucopyranoside, was discovered, and rosmarinic acid and luteolin‑7‑O‑β‑glucopyranoside exhibited the strongest antioxidant activity. Keywords: sage, Salvia officinalis, phenolic compounds, antioxidant activity.

Abstract

Ten phenolic compounds were isolated from a butanol fraction of sage extracts. Their structures were determined by spectral methods (NMR, MS, IR). Among them, a novel compound, 4-hydroxyacetophenone-4-O-β-d-apiofuranosyl-(1→6)-O-β-d-glucopyranoside, was identified. Two test systems, DPPH free radical scavenging activity and radical cation ABTS•+ scavenging activity, were used to evaluate their antioxidant activity. The most active compounds were found to be rosmarinic acid and luteolin-7-O-β-glucopyranoside. Keywords: Sage; Salvia officinalis; phenolic compounds; antioxidant activity