Concepedia

A Role for the Mitochondrial Pyruvate Carrier as a Repressor of the Warburg Effect and Colon Cancer Cell Growth

John C. Schell, Kristofor A. Olson, Lei Jiang, Amy J. Hawkins, Jonathan G. Van Vranken, Jianxin Xie, Robert A. Egnatchik, Ralph J. DeBerardinis, Jared Rutter

Molecular Cell · 2014 · 380 citations · 71 references

Open access

Concepts

Life SciencesCancer BiologyOncologyCell ProliferationCellular MetabolismMetabolic RegulationCancer MetabolismMetabolic ReprogrammingMetabolic Reprogramming In CancerMitochondrial BioenergeticsMitochondrial FunctionMitochondrial MetabolismMetabolic Alterations In CancerOxygen Consumption In TumorsPyruvate MetabolismPyruvate OxidationPyruvate Transport Into MitochondriaRedox Metabolism In CancerWarburg Effect

References

71

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data

Ethan Cerami, Jianjiong Gao, Uğur Doğrusöz et al. · Cancer Discovery · 2012 · 18.4K citations · Full text

Medicine, Bioinformatics, Oncology +15

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Jianjiong Gao, Bülent Arman Aksoy, Uğur Doğrusöz et al. · Science Signaling · 2013 · 15.9K citations · Full text

Medicine, Bioinformatics, Oncology +17

Comprehensive molecular characterization of human colon and rectal cancer

Nature · 2012 · 8.7K citations · Full text

Medicine, Molecular Biology, Oncology +16

THE METABOLISM OF TUMORS IN THE BODY

Otto Warbürg, Franz Wind, Erwin Negelein · The Journal of General Physiology · 1927 · 4.4K citations · Full text

Life Sciences, Cancer Biology, Oncology +17

ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome

Christophe Ginestier, Min Hee Hur, Emmanuelle Charafe‐Jauffret et al. · Cell stem cell · 2007 · 4K citations · Full text

Medicine, Cell Biology, Oncology +14