A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, <i>Drosophila</i> , and Humans

Daniel K. Bricker, Eric B. Taylor, John C. Schell, +13

Science

GeneticsMolecular GeneticsMitochondrial BiologyYeast Mpc1 ResultsMitochondrial Biogenesis +15

TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples

Jiaming Li, Jonathan G. Van Vranken, Laura Pontano Vaites, +13

Nature Methods

Natural SciencesMass TagsMedicineMass SpectrometryBiological Mass Spectrometry +7

A Role for the Mitochondrial Pyruvate Carrier as a Repressor of the Warburg Effect and Colon Cancer Cell Growth

John C. Schell, Kristofor A. Olson, Lei Jiang, +6

Molecular Cell

Systems BiologyMitochondrial Pyruvate CarrierMitochondrial FunctionOrganelle DynamicCancer Cell Biology +8

Structure of human Fe–S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP–ISD11 interactions

Jonathan G. Van Vranken, Edward J. Brignole, Shachin Patra, +4

Proceedings of the National Academy of Sciences

BiochemistryProtein AssemblyProtein FoldingNatural SciencesMetalloprotein +12

The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis

Jonathan G. Van Vranken, Mi-Young Jeong, Wei Peng, +4

eLife

BiosynthesisMitochondrial BiogenesisBiochemistryMitochondrial FunctionIron Metabolism +10

A proteome-wide atlas of drug mechanism of action

Dylan C. Mitchell, Miljan Kuljanin, Jiaming Li, +5

Nature Biotechnology

BiochemistryMedicineNatural SciencesPharmacologyMechanism Of Action +3

ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly

Jonathan G. Van Vranken, Sara M. Nowinski, Katie J. Clowers, +7

Molecular Cell

BiochemistryNatural SciencesAcetyl-coa-dependent Modification RequiredChemical BiologyAcp Acylation +1

Amelioration of pathologic α-synuclein-induced Parkinson’s disease by irisin

Tae‐In Kam, Hyejin Park, Shih-Ching Chou, +14

Proceedings of the National Academy of Sciences

SDHAF4 Promotes Mitochondrial Succinate Dehydrogenase Activity and Prevents Neurodegeneration

Jonathan G. Van Vranken, Daniel K. Bricker, Noah Dephoure, +4

Cell Metabolism

Neurodegenerative DiseasesMitochondrial FunctionPrevents NeurodegenerationMedicineCell Biology +1

Assessing target engagement using proteome-wide solvent shift assays

Jonathan G. Van Vranken, Jiaming Li, Dylan C. Mitchell, +2

eLife

Quantitative ProteomicsProtein ChemistryProteomic TechnologyModern Quantitative ProteomicsBiochemistry +12