Nitric Oxide Decreases the Enzymatic Activity of Insulin Degrading Enzyme in APP/PS1 Mice

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain <i>in vivo</i>

Wesley Farris, Stefan Mansourian, Yang Chang et al. · Proceedings of the National Academy of Sciences · 2003 · 1.5K citations · Full text

Nitric oxide, oxidants, and protein tyrosine nitration

Rafael Radí · Proceedings of the National Academy of Sciences · 2004 · 1.4K citations · Full text

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

Mark A. Smith, Peggy L. Richey Harris, Lawrence M. Sayre et al. · Journal of Neuroscience · 1997 · 1.2K citations · Full text

Nitric Oxide, Lipid Peroxidation, Generalized Oxidative Stress +16

Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition

Nobuhisa Iwata, Satoshi Tsubuki, Yoshie Takaki et al. · Nature Medicine · 2000 · 856 citations

Neurodegenerative Diseases, Synaptic Signaling, Degenerative Pathology +9

Co-expression of multiple transgenes in mouse CNS: a comparison of strategies

Joanna L. Jankowsky, Hilda H. Slunt, Tamara Ratovitski et al. · Biomolecular Engineering · 2001 · 822 citations

Knockout Mouse, Developmental Biology, Molecular Neuroscience +10