Concepedia

New betulinic acid derivatives induce potent and selective antiproliferative activity through cell cycle arrest at the S phase and caspase dependent apoptosis in human cancer cells

R.C. Santos, Jorge A. R. Salvador, R. Cortès, Gisela Pachón, Silvia Marín, Marta Cascante

Biochimie · 2011 · 46 citations · 32 references

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References

32

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages

Valerie A. Fadok, Dennis R. Voelker, P A Campbell et al. · The Journal of Immunology · 1992 · 3.3K citations

, , +13

Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

Emily Pisha, Heebyung Chai, Ik‐Soo Lee et al. · Nature Medicine · 1995 · 886 citations

, , +14

Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells

Valentina Zuco, Rosanna Supino, Sabina Carla Righetti et al. · Cancer Letters · 2002 · 530 citations

, , +4

Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

Simone Fulda, Carsten Scaffidi, Santos A. Susín et al. · Journal of Biological Chemistry · 1998 · 374 citations · Full text

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Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors.

Simone Fulda, Claudia Friesen, Carsten Scaffidi et al. · PubMed · 1997 · 348 citations · Full text

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