Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

Claudia Friesen, Ingrid Herr, Peter H. Krammer, +1

Nature Medicine

Hematological MalignancyReceptor/ligand SystemMedicineApoptosisImmunology +6

The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells.

Simone Fulda, Hauke Sieverts, Claudia Friesen, +2

PubMed

Cell RegulationMedicineApoptosisImmunologyPharmacology +13

Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors.

Simone Fulda, Claudia Friesen, Carsten Scaffidi, +6

PubMed

Mitochondrial DysfunctionApoptosisImmunologyPathologyCell Death +15

Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2

Ulrich Pannicke, Manfred Hönig, Isabell Hess, +9

Nature Genetics

Developmental BiologyMitochondrial BiogenesisMitochondrial FunctionCell DivisionReticular Dysgenesis +7

Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis

Simone Fulda, Éric Meyer, Claudia Friesen, +3

Oncogene

MitophagySignal TransductionMitochondrial FunctionMedicineDrug-induced Apoptosis +9

Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells

Claudia Friesen, Simone Fulda, Klaus‐Michael Debatin

Leukemia

Drug Resistance AnalysisSignal TransductionApoptosisImmunologyDeficient Activation +6

Cross-Resistance of CD95- and Drug-Induced Apoptosis as a Consequence of Deficient Activation of Caspases (ICE/Ced-3 Proteases)

Ingrid Herr, Claudia Friesen, Simone Fulda, +2

Blood

A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells

Claudia Friesen, Y Kiess, Klaus‐Michael Debatin

Cell Death and Differentiation

Reductive StressApoptosis SensitivityMedicineCritical RoleApoptosis +8

Chemosensitivity of solid tumor cellsin vitro is related to activation of the CD95 system

Simone Fulda, Claudia Friesen, Klaus‐Michael Debatin

International Journal of Cancer

Cancer ResearchCancer ImmunosurveillanceOncologyMedicineApoptosis +12

Activation of apoptosis pathways in peripheral blood lymphocytes by in vivo chemotherapy

Karsten Stahnke, Simone Fulda, Claudia Friesen, +2

Blood