R.C. Santos

Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity

R.C. Santos, Jorge A. R. Salvador, Silvia Marín et al. · Bioorganic & Medicinal Chemistry · 2009 · 116 citations · Full text

Biochemistry, Betulinic Acid, Cytotoxic Activity +4

Synthesis and structure–activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid

R.C. Santos, Jorge A. R. Salvador, Silvia Marín et al. · Bioorganic & Medicinal Chemistry · 2010 · 68 citations

Derivatives, Biochemistry, Structure–activity Relationship Study +6

Bismuth triflate-catalyzed Wagner-Meerwein rearrangement in terpenes. Application to the synthesis of the 18α-oleanane core and A-neo-18α-oleanene compounds from lupanes

Jorge A. R. Salvador, Rui M. A. Pinto, R.C. Santos et al. · Organic & Biomolecular Chemistry · 2008 · 58 citations

High Yields, Chemical Engineering, Cross-coupling Reaction +12

Antileishmanial Activity of Semisynthetic Lupane Triterpenoids Betulin and Betulinic Acid Derivatives: Synergistic Effects with Miltefosine

Maria do Céu Sousa, Raquel Varandas, R.C. Santos et al. · PLoS ONE · 2014 · 52 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Chemistry +15

New betulinic acid derivatives induce potent and selective antiproliferative activity through cell cycle arrest at the S phase and caspase dependent apoptosis in human cancer cells

R.C. Santos, Jorge A. R. Salvador, R. Cortès et al. · Biochimie · 2011 · 46 citations

Caspase Dependent Apoptosis, Medicine, Apoptosis +9