Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity

Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells

Valentina Zuco, Rosanna Supino, Sabina Carla Righetti et al. · Cancer Letters · 2002 · 521 citations

Tumor Biology, Oncogenic Agent, Medicine +9

Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors.

Simone Fulda, Claudia Friesen, Carsten Scaffidi et al. · PubMed · 1997 · 348 citations

Mitochondrial Dysfunction, Apoptosis, Immunology +17

N,N'-Carbonyldiimidazole, a New Peptide Forming Reagent¹

Rolf Paul, George W. Anderson · Journal of the American Chemical Society · 1960 · 300 citations

Molecular Sciences, Bioorganic Chemistry, George W. Andersoncite +15

Betulinic acid: A new cytotoxic agent against malignant brain-tumor cells

Simone Fulda, Irmela Jeremias, H. H. Steiner et al. · International Journal of Cancer · 1999 · 204 citations

Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types

Jan H. Kessler, Franziska B. Mullauer, Guido M. de Roo et al. · Cancer Letters · 2006 · 187 citations

Tumor Biology, Plant-derived Betulinic Acid, Medicine +9