Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Estelle Bettelli, Yijun Carrier, Wenda Gao, +5

Nature

Developmental BiologyAutoimmune DiseaseLymphocyte DevelopmentImmune Cell DevelopmentAdaptive Immune System +11

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

Vasily Ogryzko, R. Louis Schiltz, Valya Russanova, +2

Cell

ChromatinTranscriptional RegulationChromatin StructureChromatin RemodelingNatural Sciences +8

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

Deborah J. Veis, Christine M. Sorenson, John R. Shutter, +1

Cell

Autoimmune DiseaseApoptosisImmunologyPathologyCell Death +5

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

Philippe Bouillet, Donald Metcalf, David C.S. Huang, +5

Science

Clinical ImmunologyCertain Apoptotic ResponsesPreclude AutoimmunityLymphocyte DevelopmentApoptosis +16

Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy

Emanuela Zappia, Simona Casazza, Enrico Pedemonte, +9

Blood

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

Andreas Strasser, Alan W. Harris, Suzanne Cory

Cell

Perturbs Thymic Self-censorshipT-regulatory CellImmunologyCell DeathAutoimmunity +6

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

Kohei Ota, Makoto Matsui, Edgar L. Milford, +3

Nature

Autoimmune DiseaseMedicineT-regulatory CellImmunologyAntigen Processing +9

Differential Affinities of Visual Arrestin, βArrestin1, and βArrestin2 for G Protein-coupled Receptors Delineate Two Major Classes of Receptors

Robert H. Oakley, Stéphane A. Laporte, Jason A. Holt, +2

Journal of Biological Chemistry

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

Andreas Strasser, Senga Whittingham, David L. Vaux, +4

Proceedings of the National Academy of Sciences

Humoral ResponseImmunologyImmunologic MechanismImmunotherapyImmunogenetics +15

Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds

Louis M. Luttrell, Francine L. Roudabush, Eric W. Choy, +4

Proceedings of the National Academy of Sciences