David C.S. Huang

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Andrew J. Souers, Erwin R. Boghaert, Scott Ackler et al. · Nature Medicine · 2013 · 2.9K citations

Thrombopoiesis, Thrombosis, Hematological Malignancy +11

Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function

Lin Chen, Simon N. Willis, Andrew H. Wei et al. · Molecular Cell · 2005 · 1.8K citations · Full text

Medicine, Apoptosis, Immunology +7

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

Philippe Bouillet, Donald Metcalf, David C.S. Huang et al. · Science · 1999 · 1.5K citations

Clinical Immunology, Certain Apoptotic Responses, Preclude Autoimmunity +18

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized

Mark F. van Delft, Andrew H. Wei, Kylie D. Mason et al. · Cancer Cell · 2006 · 1.2K citations · Full text

Apoptosis, Immunology, Cell Death +4

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x _L , but not Bcl-2, until displaced by BH3-only proteins

Simon N. Willis, Chen Lin, Grant Dewson et al. · Genes & Development · 2005 · 1.2K citations · Full text