Ureas with histamine H3-antagonist receptor activity—A new scaffold discovered by lead-hopping from cinnamic acid amides

Carbamoylimidazolium and thiocarbamoylimidazolium salts: novel reagents for the synthesis of ureas, thioureas, carbamates, thiocarbamates and amides

Justyna A. Grzyb, Ming Shen, Chiaki Yoshina‐Ishii et al. · Tetrahedron · 2005 · 147 citations

Natural Sciences, Chemistry, Drug Discovery +1

Optimization of a Tertiary Alcohol Series of Phosphodiesterase-4 (PDE4) Inhibitors:  Structure−Activity Relationship Related to PDE4 Inhibition and Human Ether-a-go-go Related Gene Potassium Channel Binding Affinity

Richard W. Friesen, Yves Ducharme, Richard G. Ball et al. · Journal of Medicinal Chemistry · 2003 · 66 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Versatile strategies for the solid phase synthesis of small heterocyclic scaffolds: [1,3,4]-thiadiazoles and [1,3,4]-oxadiazoles

Rune Severinsen, John Paul Kilburn, Jesper Lau · Tetrahedron · 2005 · 60 citations

Pharmacy, Chemistry, Medicinal Chemistry +14

Potent <i>N</i>-(1,3-Thiazol-2-yl)pyridin-2-amine Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors with Excellent Pharmacokinetics and Low Affinity for the hERG Ion Channel

Mark T. Bilodeau, Adrienne E. Balitza, Timothy J. Koester et al. · Journal of Medicinal Chemistry · 2004 · 60 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

1-Alkyl-4-acylpiperazines as a New Class of Imidazole-Free Histamine H₃ Receptor Antagonists

Florencio Zaragoza, Henrik Stephensen, Sanne Møller Knudsen et al. · Journal of Medicinal Chemistry · 2004 · 37 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16