Yves Ducharme

Use of hydrogen bonds to control molecular aggregation. Extensive, self-complementary arrays of donors and acceptors

Yves Ducharme, James D. Wuest · The Journal of Organic Chemistry · 1988 · 156 citations

Self-complementary Arrays, Engineering, Biochemistry +14

MF63 [2-(6-Chloro-1 H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation

Daigen Xu, Steven E. Rowland, Patsy Clark et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 151 citations

<i>In Vitro</i>Characterization of MK-1439, a Novel HIV-1 Nonnucleoside Reverse Transcriptase Inhibitor

Ming‐Tain Lai, Meizhen Feng, Jean‐Pierre Falgueyret et al. · Antimicrobial Agents and Chemotherapy · 2013 · 140 citations · Full text

Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors

Bernard Côté, Louise Boulet, Christine Brideau et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 128 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +11

Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses

Bernard Côté, Jason D. Burch, Ernest Asante‐Appiah et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 97 citations

Medicine, Antiviral Drug Development, Antiviral Therapy +11