Concepedia

Lead Hopping

Lead Hopping is a drug discovery strategy that identifies novel bioactive compounds by replacing a lead compound’s core scaffold with structurally distinct yet functionally similar moieties, thereby maintaining desired biological activity while enabling significant structural divergence.

52

Publications

2.9K

Citations

445

Authors

116

Institutions

Publications per year

2017–2026

21

Parents

Publications

52

A Shape-Based 3-D Scaffold Hopping Method and Its Application to a Bacterial Protein−Protein Interaction

Thomas S. Rush, Jennifer Grant, Lidia Mosyak et al. · Journal of Medicinal Chemistry · 2005 · 605 citations · Full text

, , +14

Druggability Analysis and Structural Classification of Bromodomain Acetyl-lysine Binding Sites

Lewis R. Vidler, Nathan Brown, Stefan Knapp et al. · Journal of Medicinal Chemistry · 2012 · 273 citations · Full text

, , +15

Bioisosteric Replacement and Scaffold Hopping in Lead Generation and Optimization

Sarah R. Langdon, Peter Ertl, Nathan Brown · Molecular Informatics · 2010 · 231 citations

, , +10

“Lead Hopping”. Validation of Topomer Similarity as a Superior Predictor of Similar Biological Activities

Richard D. Cramer, Robert J. Jilek, Stefan Guessregen et al. · Journal of Medicinal Chemistry · 2004 · 125 citations

, , +17

Finding Complex Biological Relationships in Recent PubMed Articles Using Bio-LDA

Huijun Wang, Ying Ding, Jie Tang et al. · PLoS ONE · 2011 · 97 citations · Full text

, , +13

1–5 of 52

Authors

445

  1. WX
    Weiren Xu

    Tianjin Institute of Pharmaceutical Research (China), China

    2 publications · 34 citations

    2

    h-index

  2. NB
    Nathan Brown

    Institute of Cancer Research, United Kingdom

    2 publications · 504 citations

    2

    h-index

  3. RW
    Run‐Ling Wang

    Tianjin Medical University, China

    2 publications · 34 citations

    2

    h-index

  4. XW
    Xuejiao Wang

    Shanghai First People's Hospital, China

    2 publications · 34 citations

    2

    h-index

  5. AK
    Atsushi Kondo

    Kissei Pharmaceutical (Japan), Japan

    1 publications · 18 citations

    1

    h-index

1–5 of 445

Institutions

116

  1. Chinese Academy of Medical Sciences & Peking Union Medical College

    Beijing, China

    2 h-index

    13 publications

    420 citations

  2. Institute of Cancer Research

    London, United Kingdom

    2 h-index

    5 publications

    1.3K citations

  3. University of Oxford

    Oxford, United Kingdom

    2 h-index

    3 publications

    313 citations

  4. Novartis (Switzerland)

    Basel, Switzerland

    2 h-index

    12 publications

    693 citations

  5. AstraZeneca (United States)

    Wilmington, United States

    2 h-index

    11 publications

    322 citations

  6. GlaxoSmithKline (United Kingdom)

    London, United Kingdom

    2 h-index

    21 publications

    507 citations

  7. Novartis Institutes for BioMedical Research

    Basel, Switzerland

    2 h-index

    12 publications

    693 citations

  8. Rega Institute for Medical Research

    Leuven, Belgium

    2 h-index

    8 publications

    318 citations

1–8 of 116

Venues

  1. Journal of Medicinal Chemistry

    12 publications · 1.5K citations

    12

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    9 publications · 239 citations

    9

    h-index

  3. Journal of Chemical Information and Modeling

    JCIM · 8 publications · 206 citations

    8

    h-index

  4. ACS Medicinal Chemistry Letters

    5 publications · 156 citations

    4

    h-index

  5. European Journal of Medicinal Chemistry

    4 publications · 89 citations

    4

    h-index

1–5