Blood · 2005 · 44 citations · 12 references
MedicineGeneticsMolecular GeneticsMedical GeneticsPharmacogeneticsPharmacogenomicsClinical Implementation Of PharmacogeneticsDrug Metabolism GeneticsGenotyping PlatformsPharmacogenetic TestingPharmacogenomic BiomarkersPharmacogenomic TestingGamma-glutamyl TransferaseMicrosatellite MarkersUgt1a1 GenotypeWarfarin Dose OptimizationWarfarin Resistance
Warfarin is the most widely prescribed anticoagulant for thromboembolic therapy, despite a 20-fold interindividual difference in dose requirement and a narrow therapeutic range. Incorrect dosage, especially during the initial phase of treatment, carries a high risk of either severe bleeding or
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Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2
Simone Rost, Andreas Fregin, Vytautas Ivaškevičius et al. · Nature · 2004 · 1.1K citations
Identification of the gene for vitamin K epoxide reductase
Tao Li, Chun-Yun Chang, Da-Yun Jin et al. · Nature · 2004 · 706 citations
Common VKORC1 and GGCX polymorphisms associated with warfarin dose
Mia Wadelius, L Y Chen, Kate Downes et al. · The Pharmacogenomics Journal · 2005 · 467 citations