Lab on a Chip · 2009 · 91 citations · 19 references
EngineeringChemical EngineeringComputational Fluid DynamicsMicrofabricationMultiphase FlowDroplet DynamicsEmulsion FormationMicrofluidicsDesign ConstraintsDroplet FormationDroplet Formation MechanismsDroplet Size ControlDroplet Size DistributionPressure Range Extension
We here report on three parallelized designs of the new edge-based droplet generation mechanism, which, unlike existing mechanisms, produces many equally sized droplets simultaneously at a single droplet formation unit. Operation of the scaled-out systems is straight forward; only the oil inlet pressure has to be controlled to let all the units produce oil droplets, given certain basic design constraints. For systems with a typical nozzle depth of 1.2 microm, the mean droplet diameter is 7.5 microm and the coefficient of variation is below 10%. The number of droplets that is formed per unit can easily be increased by increasing the length of the unit. The stable pressure range in which monodisperse droplets are formed can be extended by small adjustments to the design. Overall, the EDGE devices are simple in design and robust in use, making them suitable for massive outscaling.
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Silicon array of elongated through‐holes for monodisperse emulsion droplets
Isao Kobayashi, Mitsutoshi Nakajima, Kyoseok Chun et al. · AIChE Journal · 2002 · 246 citations