Concepedia

Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1

Steven W. Kortum, Timothy E. Benson, Michael J. Bienkowski, Thomas L. Emmons, D. Bryan Prince, Donna J. Paddock, Alfredo G. Tomasselli, Joseph B. Moon, A. L. LABORDE, Ruth E. TenBrink

Bioorganic & Medicinal Chemistry Letters · 2007 · 41 citations · 6 references

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6

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

Takeshi Iwatsubo, Asano Odaka, Nobuhiro Suzuki et al. · Neuron · 1994 · 1.8K citations

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Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

Riqiang Yan, Michael J. Bienkowski, Mary E. Shuck et al. · Nature · 1999 · 1.4K citations

, , +14

Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase

Michel Maillard, Roy K. Hom, Timothy E. Benson et al. · Journal of Medicinal Chemistry · 2007 · 111 citations · Full text

, , +14

Conformationally biased P3 amide replacements of β-secretase inhibitors

Shawn J. Stachel, Craig A. Coburn, Thomas G. Steele et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 66 citations · Full text

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Design of potent inhibitors of human β-secretase. Part 1

John N. Freskos, Yvette M. Fobian, Timothy E. Benson et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 32 citations

, , +13