Concepedia

The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties

Thomas Näsström, Therese Fagerqvist, Mikael Barbu, Mikael Karlsson, Fredrik Nikolajeff, Alex Kasrayan, Monica Ekberg, Lars Lannfelt, Martin Ingelsson, Joakim Bergström

Free Radical Biology and Medicine · 2010 · 132 citations · 53 references

DOI

Concepts

References

53

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Mihael H. Polymeropoulos, Christian Lavedan, Elisabeth Leroy et al. · Science · 1997 · 8.2K citations

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α-Synuclein Locus Triplication Causes Parkinson's Disease

Andrew Singleton, Matthew J. Farrer, Janel Johnson et al. · Science · 2003 · 4.4K citations

, , +15

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Dominic M. Walsh, Igor Klyubin, Julia V. Fadeeva et al. · Nature · 2002 · 4.3K citations

, , +14

Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

Rakez Kayed, Elizabeth Head, Jennifer L. Thompson et al. · Science · 2003 · 4.1K citations

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The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia

J.J. Zarranz, Juan Carlos Gómez‐Esteban, Elena Lezcano et al. · Annals of Neurology · 2003 · 2.7K citations

, , +17