Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and Efficacious γ-Secretase Inhibitors

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain

Harry F. Dovey, Varghese John, J. P. Anderson et al. · Journal of Neurochemistry · 2001 · 877 citations · Full text

Protein Secretion, Neurochemical Biomarkers, Amyloid Precursor Protein +17

Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation

Gwendolyn T. Wong, Denise Manfra, Frederique M. Poulet et al. · Journal of Biological Chemistry · 2004 · 715 citations · Full text

A highly stereocontrolled, four-step synthesis of (.+-.)-lasubine II

Jack D. Brown, Michael A. Foley, Daniel L. Comins · Journal of the American Chemical Society · 1988 · 124 citations

Molecular Sciences, Chemical Measurement, Chemical Analysis +14

Additiom of Grignard reagents to 1-acyl-4-methoxypyridinum salts. An approach to the synthesis of quinolizidinones.

Daniel L Connns, Jack D. Brown · Tetrahedron Letters · 1986 · 89 citations

Natural Product Synthesis, Engineering, Grignard Reagents +7

Synthesis of streptazolin: use of the aza-Ferrier reaction in conjunction with the INOC process to deliver a unique but sensitive natural product

Alan P. Kozikowski, Pyeong Uk Park · The Journal of Organic Chemistry · 1990 · 66 citations

Engineering, Altmetric Attention Score, Bibliometrics +19