Ying‐zi Xu

Synthesis of C₁₁N₅ Marine Sponge Alkaloids:  (±)-Hymenin, Stevensine, Hymenialdisine, and Debromohymenialdisine

Ying‐zi Xu, Kenichi Yakushijin, David Horne · The Journal of Organic Chemistry · 1997 · 66 citations

Marine Biotechnology, Engineering, Ai Moiety +9

Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

Guriqbal S. Basi, Susanna S. Hemphill, Elizabeth Brigham et al. · Alzheimer s Research & Therapy · 2010 · 50 citations · Full text

Conformationally Constrained Nicotines. 1-Pyridinyl-7-azabicyclo[2.2.1]heptane and 1-Pyridinyl-8-azabicyclo[3.2.1]octane Analogues

Ying‐zi Xu, Jaesung Choi, Manuel Calaza et al. · The Journal of Organic Chemistry · 1999 · 35 citations

Diversity Oriented Synthesis, Derivatives, Engineering +14

Discovery of (<i>R</i>)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND006) and (<i>R</i>)-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch

Gary D. Probst, Danielle L. Aubele, Simeon Bowers et al. · Journal of Medicinal Chemistry · 2013 · 32 citations

Molecular Pharmacology, Medicinal Chemistry, Synthetic Strategy +14

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure–activity relationship of the aryl region

Gary D. Probst, Simeon Bowers, Jennifer M. Sealy et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 25 citations · Full text

Structure–activity Relationship, Medicinal Chemistry, Aryl Region +9