Susanna S. Hemphill

Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

Guriqbal S. Basi, Susanna S. Hemphill, Elizabeth Brigham et al. · Alzheimer s Research & Therapy · 2010 · 50 citations · Full text

Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors

Anh P. Truong, Danielle L. Aubele, Gary D. Probst et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 36 citations · Full text

Structure–activity Relationship, Medicinal Chemistry, Pharmaceutical Science +11

Discovery of (<i>R</i>)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND006) and (<i>R</i>)-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch

Gary D. Probst, Danielle L. Aubele, Simeon Bowers et al. · Journal of Medicinal Chemistry · 2013 · 32 citations

Molecular Pharmacology, Medicinal Chemistry, Synthetic Strategy +14

P3‐320: Pharmacokinetic and pharmacodynamic investigation of ELND006, a novel APP‐selective gamma‐secretase inhibitor, on amyloid‐β concentrations in the brain, CSF and plasma of multiple nonclinical species following oral administration

Elizabeth Brigham, Kevin P. Quinn, Grace Kwong et al. · Alzheimer s & Dementia · 2010 · 12 citations

Neurochemical Biomarkers, Pharmacotherapy, Pre-clinical Pharmacology +18

N-Bridged bicyclic sulfonamides as inhibitors of γ-secretase

Simeon Bowers, Gary D. Probst, Anh P. Truong et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 12 citations · Full text

Medicinal Chemistry, Biochemistry, Natural Sciences +7