Xiaocong M. Ye

Novel cinnoline-based inhibitors of LRRK2 kinase activity

Albert W. Garofalo, Marc Adler, Danielle L. Aubele et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 39 citations · Full text

Medicine, Lrrk2 Kinase Activity, Receptor Tyrosine Kinase +6

Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors

Albert W. Garofalo, Marc Adler, Danielle L. Aubele et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 33 citations · Full text

Medicinal Chemistry, Drug Target, Medicine +4

Discovery of (<i>R</i>)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND006) and (<i>R</i>)-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch

Gary D. Probst, Danielle L. Aubele, Simeon Bowers et al. · Journal of Medicinal Chemistry · 2013 · 32 citations

Molecular Pharmacology, Medicinal Chemistry, Synthetic Strategy +14

Triazolopyridazine LRRK2 kinase inhibitors

Maurizio Franzini, Xiaocong M. Ye, Marc Adler et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 31 citations · Full text

Receptor Tyrosine Kinase, Pharmacology, Mechanism Of Action +5

Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious γ-secretase inhibitors (Part II)

Xiaocong M. Ye, Andrei W. Konradi, Jenifer Smith et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 20 citations

Medicinal Chemistry, Biochemistry, Natural Sciences +12