Triazolopyridazine LRRK2 kinase inhibitors

Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology

Alexander Zimprich, Saskia Biskup, Petra Leitner et al. · Neuron · 2004 · 3K citations · Full text

Mendelian Disorder, Genetic Disorder, Parkinson Disease +5

Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease

Coro Paisán‐Ruíz, Shushant Jain, E. Whitney Evans et al. · Neuron · 2004 · 2.4K citations · Full text

Neurodegenerative Diseases, Genetic Disorder, Parkinson Disease +9

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

Andrew B. West, Darren J. Moore, Catherine Choi et al. · Human Molecular Genetics · 2007 · 598 citations

Mitophagy, Gtpase Activity, Cell Death +16

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

Wanli W. Smith, Zhong Pei, Haibing Jiang et al. · Proceedings of the National Academy of Sciences · 2005 · 412 citations · Full text

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization

Nicolas Dzamko, Mária Deák, Fayçal Hentati et al. · Biochemical Journal · 2010 · 383 citations · Full text

Mitophagy, Molecular Biology, Cytoplasmic Localization +19