A novel kavalactone derivative protects against H2O2-induced PC12 cell death via Nrf2/ARE activation

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Ken Itoh, Tomoki Chiba, Satoru Takahashi et al. · Biochemical and Biophysical Research Communications · 1997 · 4K citations

Life Sciences, Biochemistry, Molecular Biology +14

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

Sally A. Cowley · Cell · 1994 · 2K citations

Life Sciences, Developmental Biology, Molecular Biology +8

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Albena T. Dinkova‐Kostova, W. David Holtzclaw, Robert N. Cole et al. · Proceedings of the National Academy of Sciences · 2002 · 1.9K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element

Elisabeth Abidemi Balogun, Martha Hoque, Pengfei Gong et al. · Biochemical Journal · 2003 · 1K citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Carnosic acid, a <i>catechol‐type</i> electrophilic compound, protects neurons both <i>in vitro</i> and <i>in vivo</i> through activation of the Keap1/Nrf2 pathway via <i>S‐</i>alkylation of targeted cysteines on Keap1

Takumi Satoh, Kunio Kosaka, Ken Itoh et al. · Journal of Neurochemistry · 2007 · 387 citations

Life Sciences, Neurobiology, Neuroscience +14