Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1

Incidence and functional consequences of <i>hMLH1</i> promoter hypermethylation in colorectal carcinoma

James G. Herman, Asad Umar, Kornélia Polyák et al. · Proceedings of the National Academy of Sciences · 1998 · 1.9K citations · Full text

Medicine, Genetics, Oncology +17

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

M F Kane, Massimo Loda, Gretchen M. Gaida et al. · PubMed · 1997 · 1.5K citations

Life Sciences, Genetics, Oncology +17

Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

Wenqiang Yu, David Gius, Patrick Onyango et al. · Nature · 2008 · 801 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease

Cristina Tufarelli, Jackie A Sloane Stanley, David Garrick et al. · Nature Genetics · 2003 · 548 citations

Life Sciences, Genetics, Molecular Genetics +16

Germline epimutation of MLH1 in individuals with multiple cancers

Catherine M. Suter, David I. K. Martin, Robyn L. Ward · Nature Genetics · 2004 · 475 citations

Medicine, Molecular Genetics, Oncology +13