Concepedia

Phase I dose-escalation study of EZN-2208 (PEG-SN38), a novel conjugate of poly(ethylene) glycol and SN38, administered weekly in patients with advanced cancer

Amita Patnaik, Kyriakos P. Papadopoulos, Anthony W. Tolcher, Muralidhar Beeram, Larry J. Schaaf, Sanaa Tahiri, Tanios Bekaii‐Saab, François Lokiec, Keyvan Rezaï, Aby Buchbinder

Cancer Chemotherapy and Pharmacology · 2013 · 54 citations · 19 references

DOI

Concepts

References

19

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

Patrick Therasse, Susan G. Arbuck, Elizabeth A. Eisenhauer et al. · JNCI Journal of the National Cancer Institute · 2000 · 15.7K citations

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Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.

Lalitha Iyer, Christopher D. King, P. F. Whitington et al. · Journal of Clinical Investigation · 1998 · 680 citations · Full text

, , +17

Maximum likelihood estimation in nonlinear mixed effects models

Estelle Kuhn, Marc Lavielle · Computational Statistics & Data Analysis · 2004 · 475 citations

, , +8

Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats.

Kiyoshi Takasuna, Takehiro Hagiwara, Masaaki Hirohashi et al. · PubMed · 1996 · 338 citations

, , +17

Coupling a stochastic approximation version of EM with an MCMC procedure

Estelle Kuhn, Marc Lavielle · ESAIM Probability and Statistics · 2004 · 260 citations · Full text

, , +16